PDE5 Inhibitors – What You Need to Know

PDE5 inhibitors are drugs that prevent the breakdown of cGMP in the smooth muscles surrounding the penile arteries.

Sildenafil, tadalafil, and vardenafil are prescription medications used to treat erectile dysfunction (ED) and other male sexual health issues. Your doctor may prescribe these medications if they help you get an erection when you’re sexually aroused.

Since they’re so practical and their records are impressive, PDE5 inhibitor medications are the first-line treatment for erectile dysfunction.

Where is phosphodiesterase type 5 inhibitor (PDE5 inhibitor) Located?

There are many kinds of PDE5 enzymes which act to degrade cGMP (cyclic guanosine monophosphate). They’re found in many body parts and carry out their activities in various tissues.

An enzyme called phosphodiesterase type 5 (PDE5) is present in the smooth muscles of the corpus cavernous, skeletal muscles, cerebellum, pancreas, blood vessels, lung tissue, and kidney tissue.

Can PDE5 inhibitors cure erectile dysfunction (ED)?

PDE5 inhibitors cause vasodilatation in the penis region, prevent the breakdown of cGMP and result in the prolonged action of mediators of vasodilators like nitric oxides. Erection depends on the release of nitric oxides, which stimulate cGMP production.

Erection is a physiological response when nerves release nitric oxide into the blood vessels supplying the penis. Nitric oxide relaxes the smooth muscle cells in the corpora cavernosa, causing them to expand and fill with blood, resulting in an erection.

Cialis comes in two forms – Tadalafil (CIALIS) and Dapoxetine (DAPOXETINE). Both these drugs work by increasing levels of nitric oxide in the body. Nitric oxide relaxes muscles around blood vessels and helps them widen so that more blood can enter the erectile tissue.

When Should I Take PDE5?

Drugs that belong to phosphodiesterase type 5 (PDE5) inhibitors treat three men’s conditions: erectile dysfunction, pulmonary arterial hypertension (PAH), and benign prostatic hypertrophy (BPH).

Erectile dysfunction (ED) is one of the most commonly reported sexual issues among men. ED occurs when a man cannot achieve an adequate level of arousal for successful penetration. Physical conditions, psychological disorders, medications, or lifestyle choices may cause ED.

Pulmonary arterial Hypertension (PAH) occurs when the pulmonary artery pressure increases above 25mm Hg. PAH is characterized by increased resistance to flow through the pulmonary vasculature.

Benign Prostatic Hyperplasia (BPH) is a common condition among older males by age 50. It is when the rapid increase of the stromal cells in the prostatic tissue causes an enlarged prostatic gland.

Which are the best PDE5 Inhibitors ?

Sildenafil

One notes that the oral doses of Sildenafil expect an onset of action in thirty minutes and the estimated maximum effects at one hundred minutes.

However, the half-life of this medication is four (4) hrs. Also, this medication is a lipophilic compound, so taking a dose near the time of eating a fatty meal decreases its effectiveness.

There are other options for erectile dysfunction treatment aside from Viagra. Here are some examples: Cenforce 100 mg.

Tadalafil

Tadalafil (Cialis) treats erectile dysfunction and benign prostatic hypertrophy. Adcirca (Pulmonary Arterial Hypertensión) is used to treat pulmonary arterial hypertension.

Tadalafil works best when taken within 2 hours before eating. However, consuming a meal doesn’t affect its effectiveness.

Vardenafil

Vardenafil (Levitra) is used to treat erectile dysfunctions.

Vardenafil works by relaxing muscles in the penile region so that they become less tight during sex. It remains effective for up to seven (7) hrs.

FAQs

What is PDE5?

Caffeine, which is present in most people’s daily diet, has a mixed reputa­tion for treating erectile dysfunc­tion. However, phosphodiesterase 5 (PDE5) enzymes break down cGMP inside cells.

Side Effects Of PDE5 Inhibitors: What Are They?

ED drugs can cause the side effect of headaches, flushing, nasal congestion, dizziness, diarrhea, nausea, vomiting, back pain, and heartburn.

Headaches, flushes, stomach discomfort, muscle and back pain, and even nausea are common side effects of a cold.

The following are examples of uncommon but not rare adverse events:

Changes in eyesight and sudden loss of sight are more common among people with heart disease or diabetes or an unexpected loss of sound. Prolonged or painful erections that need medical help to prevent lasting damage.

3 What fruit is a natural Viagra?

According to one study by researchers at the University of California, Los Angeles, watermelons may contain a compound called citrulline that could help treat sexual dysfunctions like impotence.

What is PDE5?

Viagra is one of the most potent and well-known PDE5 inhibitors used by doctors.

What are PDE5 inhibitors?

It would help if you took PDE5 inhibitors only under medical supervision. If you’re taking any medication or suffer from a condition, you should consult your physician before using these drugs.

Do I need a prescription for Viagra?

Over-the-coun­ter sales of PDE5 inhibitors are illegal. They’re not safe for use without a doctor’s prescription.

7 What if a guy took Viagra?

The FDA has approved Viagra for the treatment of male impotence. There is no female equivalent of Viagra. However, some medications have been approved to help females with sexual dysfunctions.

A variety of factors may cause low sexual desire in females. Consult your physician before taking any medication. Ask about the drug’s possible benefits and risks.

Erectile dysfunction (ED) may be caused by heart disease.

If you’re having trouble achieving or maintaining an erection, you may want to talk to your doctor about whether there could be a connection between these two conditions. Likewise, if you’re taking medications for heart health, they may help improve your ability to achieve or sustain an erection.

These PDE5 inhibitors should be taken only on medical advice as they may interact with certain medicines, including nitrates. Your physician will guide all the relevant details and any precautions you need to take when using them.