Kary Uni, Pirenoxine Uses
Kary Uni Ophthalmic Suspension
(Pirenoxine) is an anti-cataract agent used to inhibit the development of cataracts in patients considered at risk. Its mechanism of action is interacting with calcium and selenite ions, which are known to play a central role in the formation of lens cataracts. This in turn can help stop crystals in the eye that are water soluble from insolubilization, which allows for the eye lens and vision to remain clear. Another medical study showed that it might be effective in helping preventing an oxidative attack on the eye lens, which could further explain its potential as a treatment for cataract prevention.
Pirenoxine Dosage and Administration
(Pirenoxine) eye drops need to be administered strictly as directed by the physician in charge of treatment. To use them, place the tablet into the solvent (provided in the bottle) and allow it to fully dissolve. It may be necessary to shake it. Your physician will direct you with regard to proper use, as well as how often it needs to be applied. Adults are sometimes told to administer 1 to 2 drops, 3 to 5 times every day. However, a different dosage regimen may be needed by some patients, depending on the severity of symptoms. Therefore, it is essential that all instructions given by the physician in charge of treatment are strictly followed.
Pirenoxine is a preparation of 1-hydroxy-5-oxo-5H-pyrido(3,2-α)-phenoxazine-3-carboxylic acid, a compound having a chemical structure similar to xanthommatin, an eye pigment of the insect, with a pyridophenoxazone nucleus.
The solvent is isotonic, buffered solution containing 0.02% methylparaben, 0.01% propylparaben and 0.0001% thimerosal as preservatives.
Pirenoxine Mechanism of action
Though the pathogenesis of cataracts has not yet been clearly determined, conversion of water-soluble protein in the lens to insoluble protein by quinone substances produced as the result of abnormal metabolism of aromatic amino acid, is said to be responsible for cataracts according to “Quinoid Theory” established as the result of biochemical study on lens protein in the Dept. of Ophthalmology, Osaka University Medical School. Pirenoxine is found to competitively inhibit the action of the quinone substances. Extensive experiments, both basic and clinical, have proven that this agent prevents the progress of cataracts.
Ophthalmic soln 0.75 mg/tab x 15 mL x 1’s.
Pirenoxine Side effects
You must make your physician aware of any side effects that occur while you are using Kari Uni (Pirenoxine) eye drops. Possible reactions could include:
- Mildly painful eyes
- Slightly foggy vision
- Eye sensitivity to light
- Inflammation which affects the eyelids
- Sensing that there is an object in the eye
Patients should also take note of the fact that some adverse events which have not been referenced here may occur. You will need to get medical attention immediately if you suffer from any serious side effects.
Kari Uni (Pirenoxine) is only for ophthalmic use. Under no circumstances should it be ingested or applied to other locations on the body apart from the eyes.
Once you have placed the tablets in the solvent for dissolution, the solution will need to be used within a period of 3 weeks. Any unused solution after this should be disposed of.