Zendryl, Diphenhydramine hydrochloride Uses

Diphenhydramine hydrochloride

Codiphen, Diphenhydramine provides temporary relief of upper respiratory allergies an hay fever.
It also relieves affections associated with a common cold, such as sneezing and runny nose.

Diphenhydramine HCI Composition

Each tablet contains : Diphenhydramine hydrochloride 50 mg.

DIPHENHYDRAMINE HCI ACTION

Diphenhydramine hydrochloride is ethanolamine – derivative, first generation antihistamines: anticholinergic and sedative effects by competing with histamine for H1 – receptor sites on effector cells.

Diphenhydramine Indications

• Hypersensitivity reactions. Type I (immediate).
  Perennial and seasonal allergic rhinitis.
  Allergic conjunctivitis due to inhalant allergens and foods.
  Mild, uncomplicated allergic skin manifestation of urticaria and angioedema.
  Amelioration of allergic reactions to blood or plasma in patients with a know history of such reactions.
  Dermographism
  As adjunctive anaphylactic therapy.
• Effective for the prevention and treatment of nausea, vomiting, and / or vertigo associated with motion sickness.
• Antiparkinsonism
  Parkinsonism (including drug – induced) in the elderly unable to tolerate more potent agents.
  Mild cases of parkinsonism (including drug – induced) in other age groups.
  In other cases of parkinsonism (including drug – induced) in combination with centrally acting anticholinergic agent.
• Sleep disorders (oral only); as a nighttime sleep aid.

DOSAGE AND ADMINISTRATION

Hypersensitivity reactions (nasal allergies and allergic dermatosis)
Antiparkinsonism
Adults and children 12 years of age and over:
– ½ to 1 tablet (25 to 50 mg) every 4-6 hours, not to exceed 6 tablets (300 mg) in 24 hours.
Children 6 to 12 years of age :
-¼ to 1 tablet (12,5 to 25 mg) every 4 – 6 hours,  or 5 mg / kg / day, not exceed 3 tablets (150 mg) in 24 hours.

Motion sickness
Adults and children 12 years of age and over:
-1 tablet (50 mg) before exposure to motion or before meals and at bedtime.
Children 6 to 12 years of age:
– ½ tablet (25 mg) before exposure to motion or before meals and at bedtime.

Sleep disorders
Adults and children 12 years or age and over:
1 tablet (50 mg) at bedtime.
Children 2 to 12 years :
1 mg / kg given 30 minutes before retiring

CONTRAINDICATION

Hypersensitivity to any ingredient of the product or any component of the formulation.

WARNINGS

Causes sedation, caution must be used in performing tasks which require alertness (ie, operating machinery or driving).
Sedative effects of CNS depressants or ethanol are potentiated. Use with caution in patients with angle – closure glaucoma, pyloroduodenal obstruction (including stenotic peptic ulcer), urinary tract obstruction (including bladder – neck obstruction and symptomatic prostatic hypertrophy), hyperthyroidism, increased intraocular pressure, and cardiovascular disease (including hypertension and tachycardia). Diphenhydramine has high sedative and anticholinergic properties, so it may not be considered the antihistamine of choice for prolonged use in the elderly.

STORAGE CONDITION
Store at 20 -28 °C

More info on Diphenhydramine HCI

Diphenhydramine