Zunestar (Eszopiclone) 3mg

Price/Pill: $2.17
Generic Name: Ezopiclone
Manufacturer: Habpharma

Eszopiclone is used to treat a certain sleep problem (insomnia). It may help you fall asleep faster, stay asleep longer, and lessen how often you wake up during the night, so you can get a better night’s rest. Eszopiclone belongs to a class of drugs called sedative-hypnotics.


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What is the difference between zopiclone and eszopiclone?

The eszopiclone/zopiclone difference is in the dosage—the strongest eszopiclone dosage contains 3 mg of the therapeutic stereoisomer, whereas the highest zopiclone dosage (10 mg) contains 5 mg of the active stereoisomer.

Is eszopiclone a narcotic?

Is this medication considered a controlled substance or narcotic? Yes. Lunesta (eszopiclone) is a Schedule IV controlled substance, which can potentially lead to physical and mental dependence.

What is the drug eszopiclone used for?

Eszopiclone is used to treat insomnia (difficulty falling asleep or staying asleep). Eszopiclone is in a class of medications called hypnotics. It works by slowing activity in the brain to allow sleep.

Is 3 mg of Eszopiclone a lot?

The recommended starting dose of Lunesta has been decreased from 2 mg to 1 mg for men and women. The 2 mg and 3 mg doses could lead to next-day impairment of activities requiring alertness such as driving.

Is Lunesta similar to Xanax?

Lunesta and Xanax belong to different drug classes. Lunesta is a sedative hypnotic and Xanax is a benzodiazepine. Side effects of Lunesta and Xanax that are similar include drowsiness, dizziness, problems with memory or concentration, headache, nausea, changes in appetite, constipation, or dry mouth.

Is it OK to take Lunesta every night?

Lunesta is more likely to help you stay asleep the whole night, but its longer period of action may mean more carry-over effects the next day, particularly for seniors. Clearly, though, what many patients want is a medication that they can take every night for an indefinite period.

Does Lunesta work better than Ambien?

However, Lunesta is longer acting. It may be more effective in helping you stay asleep than the immediate-release form of Ambien. That said, the extended-release form of Ambien may help you stay asleep longer.

What is the best medication for chronic insomnia?

Some of the prescription medications that are approved for treating insomnia include:

zolpidem (Ambien)
eszopiclone (Lunesta)
zaleplon (Sonata)
doxepin (Silenor)
ramelteon (Rozerem)
suvorexant (Belsomra)
temazepam (Restoril)

What is Eszopiclone?

Eszopiclone (Eszopiclone) is a sedative, also called a hypnotic. It affects chemicals in your brain that may be unbalanced in people with sleep problems (insomnia).

Eszopiclone is used to treat insomnia. This medicine causes relaxation to help you fall asleep and stay asleep.

Eszopiclone may also be used for purposes not listed in this medication guide.

Eszopiclone indications

An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.

Eszopiclone® (Eszopiclone) is indicated for the treatment of insomnia. In controlled outpatient and sleep laboratory studies, Eszopiclone administered at bedtime decreased sleep latency and improved sleep maintenance.

The clinical trials performed in support of efficacy were up to 6 months in duration. The final formal assessments of sleep latency and maintenance were performed at 4 weeks in the 6-week study (adults only), at the end of both 2-week studies (elderly only), and at the end of the 6-month study (adults only).

How should I use Eszopiclone?

Use Eszopiclone as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Eszopiclone comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Eszopiclone refilled.
  • Take Eszopiclone by mouth. Do not take Eszopiclone with, or immediately after, a meal.
  • Eszopiclone works very quickly. Take it right before getting into bed. This will help to decrease the risk of falling and other side effects.
  • If you miss a dose of Eszopiclone and you are taking 1 dose daily at bedtime, skip the missed dose. Do not take the dose in the morning or take 2 doses at once.

Ask your health care provider any questions you may have about how to use Eszopiclone.

Uses of Eszopiclone in details

There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for a prolonged period to get the benefit from it.

Eszopiclone is used to treat sleep-related problems like difficulty falling asleep or staying asleep (insomnia).

Eszopiclone description

Eszopiclone, marketed by Sepracor under the brand-name Eszopiclone, is a nonbenzodiazepine hypnotic agent (viz., a sedative) used as a treatment for insomnia. Eszopiclone is the active stereoisomer of zopiclone, and belongs to the class of drugs known as cyclopyrrones. Its main selling point is that it is approved by the U.S. Food and Drug Administration for long-term use, unlike almost all other hypnotic sedatives, which are approved only for the relief of short-term (6-8 weeks) insomnia.

Eszopiclone dosage

Use the lowest effective dose for the patient.

Dosage In Adults

The recommended starting dose is 1 mg. Dosing can be raised to 2 mg or 3 mg if clinically indicated. In some patients, the higher morning blood levels of Eszopiclone following use of the 2 mg or 3 mg dose increase the risk of next day impairment of driving and other activities that require full alertness. The total dose of Eszopiclone should not exceed 3 mg, once daily immediately before bedtime.

Geriatric Or Debilitated Patients

The total dose of Eszopiclone should not exceed 2 mg in elderly or debilitated patients.

Patients With Severe Hepatic Impairment, Or Taking Potent CYP3A4 Inhibitors

In patients with severe hepatic impairment, or in patients coadministered Eszopiclone with potent CYP3A4 inhibitors, the total dose of Eszopiclone should not exceed 2 mg.

Use With CNS Depressants

Dosage adjustments may be necessary when Eszopiclone is combined with other CNS depressant drugs because of the potentially additive effects.

Administration With Food

Taking Eszopiclone with or immediately after a heavy, high-fat meal results in slower absorption and would be expected to reduce the effect of Eszopiclone on sleep latency.

How supplied

Dosage Forms And Strengths

Eszopiclone is available in 1 mg, 2 mg and 3 mg strengths for oral administration.

Eszopiclone 3 mg tablets are round, dark blue, film-coated, and identified with debossed markings of S193 on one side.

Eszopiclone 2 mg tablets are round, white, film-coated, and identified with debossed markings of S191 on one side.

Eszopiclone 1 mg tablets are round, light blue, film-coated, and identified with debossed markings of S190 on one side.

Storage And Handling

Eszopiclone 3 mg tablets are round, dark blue, film-coated, and identified with debossed markings of S193 on one side, and are supplied as:

NDC 63402-193-10 bottle of 100 tablets

Eszopiclone 2 mg tablets are round, white, film-coated, and identified with debossed markings of S191 on one side, and are supplied as:

NDC 63402-191-10 bottle of 100 tablets

Eszopiclone 1 mg tablets are round, light blue, film-coated, and identified with debossed markings of S190 on one side, and are supplied as:

NDC 63402-190-30 bottle of 30 tablets

Store at 25°C (77°F); excursions permitted to 15°C to 30°C (59°F to 86°F).

Manufactured for: Sunovion Pharmaceuticals Inc., Marlborough, MA 01752 USA. Revised: May 2014

Eszopiclone interactions

CNS-Active Drugs


An additive effect on psychomotor performance was seen with coadministration of Eszopiclone and ethanol 0.70 g/kg for up to 4 hours after ethanol administration.


Coadministration of single doses of Eszopiclone 3 mg and paroxetine 20 mg daily for 7 days produced no pharmacokinetic or pharmacodynamic interaction.


Coadministration of single doses of Eszopiclone 3 mg and lorazepam 2 mg did not have clinically relevant effects on the pharmacodynamics or pharmacokinetics of either drug.


Coadministration of Eszopiclone 3 mg and olanzapine 10 mg produced a decrease in DSST scores. The interaction was pharmacodynamic; there was no alteration in the pharmacokinetics of either drug.

Drugs That Inhibit CYP3A4 (Ketoconazole)

CYP3A4 is a major metabolic pathway for elimination of Eszopiclone. The AUC of Eszopiclone was increased 2.2-fold by coadministration of ketoconazole, a potent inhibitor of CYP3A4, 400 mg daily for 5 days. Cmax and t1/2 were increased 1.4-fold and 1.3-fold, respectively. Other strong inhibitors of CYP3A4 (e.g., itraconazole, clarithromycin, nefazodone, troleandomycin, ritonavir, nelfinavir) would be expected to behave similarly.

Drugs That Induce CYP3A4 (Rifampicin)

Racemic zopiclone exposure was decreased 80% by concomitant useof rifampicin, a potent inducer of CYP3A4. A similar effect would be expected with Eszopiclone.

Drugs Highly Bound To Plasma Protein

Eszopiclone is not highly bound to plasma proteins (52-59% bound); therefore, the disposition of Eszopiclone is not expected to be sensitive to alterations in protein binding. Administration of Eszopiclone 3 mg to a patient taking another drug that is highly protein-bound would not be expected to cause an alteration in the free concentration of either drug.

Drugs With A Narrow Therapeutic Index


A single dose of Eszopiclone 3 mg did not affect the pharmacokinetics of digoxin measured at steady state following dosing of 0.5 mg twice daily for one day and 0.25 mg daily for the next 6 days.


Eszopiclone 3 mg administered daily for 5 days did not affect the pharmacokinetics of (R)- or (S)-warfarin, nor were there any changes in the pharmacodynamic profile (prothrombin time) following a single 25 mg oral dose of warfarin.

Eszopiclone side effects

Applies to Eszopiclone: oral tablet

In addition to its needed effects, some unwanted effects may be caused by Eszopiclone (the active ingredient contained in Eszopiclone). In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking Eszopiclone:

More common:

  • Cough or hoarseness
  • fever or chills
  • lower back or side pain
  • painful or difficult urination
  • sleepiness or unusual drowsiness

Less common:

  • Bladder pain
  • bloody or cloudy urine
  • cold flu-like symptoms
  • confusion
  • difficult, burning, or painful urination
  • discouragement
  • fear or nervousness
  • feeling sad or empty
  • frequent urge to urinate
  • irritability
  • lack of appetite
  • loss of interest or pleasure
  • nerve pain
  • seeing, hearing, or feeling things that are not there
  • tiredness
  • trouble concentrating
  • trouble sleeping

Minor Side Effects

Some of the side effects that can occur with Eszopiclone may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common:

  • Acid or sour stomach
  • bad, unusual, or unpleasant (after) taste
  • belching
  • change in taste
  • dizziness
  • dry mouth
  • headache
  • heartburn
  • indigestion
  • nausea
  • pain
  • stomach discomfort, upset, or pain

Less common:

  • Abnormal dreams
  • accidental injury
  • decreased interest in sexual intercourse
  • diarrhea
  • inability to have or keep an erection
  • pain, cramps, or heavy bleeding (females)
  • rash
  • swelling of the breasts or breast soreness (in both males and females)
  • vomiting

Incidence not known:

  • Loss of memory
  • problems with memory

Eszopiclone contraindications

Eszopiclone may cause a severe allergic reaction. Stop taking Eszopiclone and get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Eszopiclone will make you fall asleep. Never take this medication during your normal waking hours, unless you have at least 8 hours to dedicate to sleeping.

Some people using this medicine have engaged in activity such as driving, eating, or making phone calls and later having no memory of the activity. If this happens to you, stop taking Eszopiclone and talk with your doctor about another treatment for your sleep disorder.

Eszopiclone can cause side effects that may impair your thinking or reactions. You may still feel sleepy the morning after taking the medication. Until you know how this medication will affect you during waking hours, be careful if you drive, operate machinery, pilot an airplane, or do anything that requires you to be awake and alert.

Do not drink alcohol while you are taking Eszopiclone. It can increase some of the side effects of Eszopiclone, including drowsiness.

Eszopiclone may be habit-forming and should be used only by the person it was prescribed for. Eszopiclone should never be shared with another person, especially someone who has a history of drug abuse or addiction. Keep the medication in a secure place where others cannot get to it.

You may have withdrawal symptoms if you stop taking Eszopiclone after taking it over several days in a row. Do not stop taking Eszopiclone suddenly without first talking to your doctor. You may need to use less and less before you stop the medication completely.


Active ingredient matches for Eszopiclone:


Unit description / dosage (Manufacturer)Price, USD Lunesta 2 mg tablet$ 8.08 Lunesta 3 mg tablet$ 7.28 Lunesta 1 mg tablet$ 7.24 Eszopiclone tablet, film coated 3 mg/1 (bryant ranch prepack (US)) Eszopiclone tablet, film coated 2 mg/1 (Orchid Pharma Inc (US)) Eszopiclone tablet, film coated 1 mg/1 (Aurobindo Pharma Limited (US)) Eszopiclone tablet 3 mg/1 (West Ward Pharmaceuticals Corp. (US)) Eszopiclone tablet 1 mg/1 (Proficient Rx LP (US)) Eszopiclone tablet, coated 3 mg/1 (Dr. Reddy’s Laboratories Limited (US)) Eszopiclone tablet 2 mg/1 (Proficient Rx LP (US)) Eszopiclone tablet, coated 2 mg/1 (Dr. Reddy’s Laboratories Limited (US)) Eszopiclone tablet, coated 1 mg/1 (Dr. Reddy’s Laboratories Limited (US))

List of Eszopiclone substitutes (brand and generic names):

Eszop (Chile) Tablet; Oral; Eszopiclone 3 mg (Silesia) Exopil (Chile) Ezolin (Colombia, Peru) Fulnite (India) Fulnite Capsule/ Tablet / 2mg / 10 units (Sun Pharmaceutical Industries Ltd.)$ 1.02 1 mg x 10’s (Sun Pharmaceutical Industries Ltd.)$ 0.70 2 mg x 10’s (Sun Pharmaceutical Industries Ltd.)$ 0.97 Fulnite 1mg TAB / 10 (Sun Pharmaceutical Industries Ltd.)$ 0.70 Fulnite 2mg TAB / 10 (Sun Pharmaceutical Industries Ltd.)$ 0.97 Fulnite 1 mg Tablet (Sun Pharmaceutical Industries Ltd.)$ 0.07 Fulnite (Sun Pharmaceutical Industries Ltd.)$ 0.11 FULNITE 2 MG TABLET 1 strip / 10 tablets each (Sun Pharmaceutical Industries Ltd.)$ 1.42 FULNITE tab 1 mg x 10’s (Sun Pharmaceutical Industries Ltd.)$ 0.70 FULNITE tab 2 mg x 10’s (Sun Pharmaceutical Industries Ltd.)$ 0.97 Fulnite 2mg Tablet (Sun Pharmaceutical Industries Ltd.)$ 0.16 Fulnite – 1 Fulnite – 1 Capsule/ Tablet / 1mg / 10 units (Sun Pharmaceuticals)$ 0.67 Gen-Zopiclone (Canada) Tablet; Oral; Zopiclone 5 mg Tablet; Oral; Zopiclone 7.5 mg Tablets; Oral; Zopiclone 5 mg Tablets; Oral; Zopiclone 7.5 mg Imovane (Antigua & Barbuda, Argentina, Australia, Bahamas, Bangladesh, Barbados, Belgium, Bermuda, Brazil, Canada, Cayman Islands, Chile, Denmark, Estonia, Finland, France, Georgia, Greece, Haiti, Hong Kong, Hungary, Iceland, Israel, Italy, Jamaica, Latvia, Lithuania, Luxembourg, Malaysia, Mexico, Netherlands, Netherlands Antilles, New Zealand, Norway, Poland, Romania, Russian Federation, Saint Lucia, Saint Vincent & The Grenadines, Singapore, Sweden, Switzerland, Taiwan, Trinidad & Tobago, Turkey) Tablet, Film-Coated; Oral; Zopiclone 3.75 mg Tablet, Film-Coated; Oral; Zopiclone 7.5 mg Tablet; Oral; Zopiclone 5 mg Tablet; Oral; Zopiclone 7.5 mg Imovane 7.5 mg x 10 x 20’s Imovane 7.5 mg x 20’s Imovane 7.5 mg x 5 Tablet Imovane 7.5 mg x 14 Tablet Imovane 7.5 mg x 20 Tablet Tablets, Film-Coated; Oral; Zopiclone 3.75 mg Tablets, Film-Coated; Oral; Zopiclone 7.5 mg Tablets; Oral; Zopiclone 5 mg Tablets; Oral; Zopiclone 7.5 mg Inductal (Argentina) Isoklon (Colombia) JUSTSLEEP (India) JUSTSLEEP tab 2 mg x 10’s (Emcure)$ 1.25 Lunesta Tablet; Oral; Eszopiclone 1 mg Tablet; Oral; Eszopiclone 2 mg Tablet; Oral; Eszopiclone 3 mg Lunesta tablet 2 mg (Sunovion Pharmaceuticals Canada Inc (Canada)) Lunesta tablet, coated 3 mg/1 (Unit Dose Services (US)) Lunesta tablet, coated 2 mg/1 (St Marys Medical Park Pharmacy (US)) Lunesta tablet 3 mg (Sunovion Pharmaceuticals Canada Inc (Canada)) See 151 substitutes for Eszopiclone


  1. DailyMed. “ESZOPICLONE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).”. https://dailymed.nlm.nih.gov/
  2. PubChem. “Eszopiclone”. https://pubchem.ncbi.nlm.nih.gov/
  3. DrugBank. “Eszopiclone”. http://www.drugbank.ca/drugs/
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